Depo-Provera
Recent studies have linked Depo-Provera, a contraceptive manufactured by Pfizer, to higher risks of developing meningiomas, or brain tumors that are typically benign.
Despite usually not being cancerous, meningiomas can cause disruptive symptoms, grow to become life-threatening, and may require risky or invasive surgery to remove.
If you’ve developed a brain tumor after long-term use of Depo-Provera, you may be eligible to file a lawsuit. Call 1-800-LAW-FIRM or fill out the following form for a free consultation.
Depo-Provera Lawsuit Update (November 2026)
- Thousands of cases are in federal court. As of November 2, 2026, 6,413 lawsuits were pending in MDL No. 3140 in the Northern District of Florida before Judge M. Casey Rodgers.
- Most existing claims are settling. A settlement announced on June 15, 2026 is expected to resolve most of the claims in the MDL and in New York state court. The court estimated that about 80% of MDL plaintiffs are eligible. The terms are confidential, and this is not a class action.
- The settlement registration deadline is November 30, 2026. On October 29, 2026, the court approved the fund that will be used to pay settlements.
- The litigation continues for other cases. Cases that are not part of the settlement, including newly filed cases, continue in court under the judge’s case management orders.
- The FDA label now warns of meningioma. In December 2025, the FDA approved updated Depo-Provera labeling that warns about the risk of meningioma.
Last updated November 6, 2026. This update is general information, not legal advice.
What Is Depo-Provera?
Depo-Provera, the brand name for medroxyprogesterone acetate, is an injectable contraceptive used roughly every three months. Depo-Provera is also commonly used to treat hormonal and menstrual conditions.
Roughly one in four women surveyed by the National Center for Health Statistics between 2015 and 2019 said they had used Depo-Provera before, according to a 2023 study. The data included interviews with more than 10,000 women who said they had experienced sexual intercourse with a man at least once.
What Is The Tumor Risk of Depo-Provera?
In March 2024, the British Medical Journal published a French study linking prolonged use of Depo-Provera to the development of brain tumors. The study, which looked at more than 18,000 women who had surgery to remove meningiomas, found that patients who used Depo-Provera for more than a year were more than five times as likely to have developed them.
Pfizer acknowledged the BMJ study, and in December 2025 the FDA approved updated Depo-Provera labeling that warns about the risk of meningioma.
Other studies have identified a link between meningiomas and similar substances to Depo-Provera in 2022 and to Depo-Provera specifically in 2023.
Pfizer is simply not doing enough to warn patients about the risks of Depo-Provera. If you or a loved one was diagnosed with a meningioma after long-term use of Depo-Provera, you might be able to file a lawsuit. Call 1-800-LAW-FIRM today for a free consultation.
Frequently Asked Questions
Are There Already Depo-Provera Brain Tumor Lawsuits?
Yes. Thousands of lawsuits against Pfizer and others are combined in MDL No. 3140 in the Northern District of Florida, with 6,413 pending as of November 2, 2026. An MDL groups similar lawsuits for pretrial proceedings. It is not a class action, so each person keeps their own case. A settlement announced in June 2026 is expected to resolve most existing claims, and cases outside it continue in court.
Am I Eligible for a Depo-Provera Brain Tumor Lawsuit?
Any woman who used Depo-Provera or one of its authorized generic versions multiple times and was later diagnosed with a meningioma may be eligible for a brain tumor lawsuit. Eligibility depends on the facts of each case, and the June 2026 settlement has its own criteria and deadlines. If you have used the medications for a prolonged period, you are more likely to have a valid claim.
Claimants from Alabama, Kentucky, Louisiana, Mississippi, Tennessee, and Texas may encounter additional legal issues. If you are uncertain about your eligibility, please contact us for a free consultation.
I Stopped Taking Depo-Provera Years Ago. Will I Still Be Able to File a Claim?
Possibly. The answer will likely depend on your state’s application of a so-called “discovery rule”.